Research Paper Volume 7, Issue 1 pp 26—37

Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells


Figure 1. Unsupervised hierarchical clustering heat map of signaling pathways for dataset E-MTAB-2086. Up- and down-regulated pathways are depicted in red and blue color, respectively. The first two clustered samples on the left-hand side of schematic represent the cells with maximum passages of eighty, then follow three samples that underwent 70 passages and four samples grown for 50 passages.