Research Paper Volume 7, Issue 1 pp 38—51

Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination


Figure 3. A plasma cell gene signature is enriched among vaccine responders. GSEA [35] was used to calculate the enrichment of the plasma cell signature from Nakaya et al. [7] in young, older and frail cohorts, broken down by responder and non-responder status. A signature activity of zero indicates the absence of enrichment. False discovery rates by GSEA were statistically significant for young vaccine responders at day 7 (FDR=0.01) and day 28 (FDR=0.03) post-vaccine, for young non-responders at day 28 (FDR=0.02) post-vaccine, and for frail non-responders at day 28 (FDR=0.04) post-vaccine. FDR values for all other time points and groups were not significant (FDR > 0.05).