Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination
Figure 3.A plasma cell gene signature is enriched among vaccine responders. GSEA  was used to calculate the enrichment of the plasma cell signature from Nakaya et al.  in young, older and frail cohorts, broken down by responder and non-responder status. A signature activity of zero indicates the absence of enrichment. False discovery rates by GSEA were statistically significant for young vaccine responders at day 7 (FDR=0.01) and day 28 (FDR=0.03) post-vaccine, for young non-responders at day 28 (FDR=0.02) post-vaccine, and for frail non-responders at day 28 (FDR=0.04) post-vaccine. FDR values for all other time points and groups were not significant (FDR > 0.05).