Research Paper Volume 7, Issue 1 pp 38—51

Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination


Figure 4. Pathway activities in response to vaccine. QuSAGE [34] was used to screen a subset of immunological pathways from the KEGG database to identify pathways with significantly (FDR<0.005) altered activity (rows) during one or more time-points (x-axis) in at least one of the age-groups. Three major clusters indicated by A, B and C were detected. Coloring represents down-regulated (yellow) to up-regulated (blue) activity relative to the pre-vaccination time-point. +R indicates vaccine responder status, -R indicates non-responder status. See Supplementary Table 4A for a tabulation of pathway activities and Supplementary Table 4B for a list of associated FDR values. In the figure, time-points with FDR<0.05 are indicated with an asterisk.