Research Paper Volume 7, Issue 1 pp 38—51

Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination


Figure 7. Enrichment of response and OXPHOS signature in published studies of influenza vaccine response. Each row indicates a pathway gene set and each column represents a separate publicly available dataset (indicated by GEO accession number) evaluating influenza vaccine response. Average fold-changes for a gene set with respect to the study-specific baseline are shown for varying times after vaccination as indicated for general ranges at the top of the figure and in hours (h) or days (d) at the bottom of the figure following each GEO accession number. QuSAGE [34] was used to assess the activity of a subset of immunological pathways from the KEGG database and response signature in published studies, with significance (FDR<0.05) depicted by an asterisk. Pathways enriched in a minimum of five columns are depicted. The vaccine response signature described in this report is denoted as “Yale Response” (arrow). Coloring represents down-regulated (blue) to up-regulated (red) activity relative to the pre-vaccination time-point.