Research Paper Volume 7, Issue 1 pp 70—81

Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway


Figure 5. Arg-II gene deficiency in mice (Arg-II−/−) prevents age-associated enhanced p38 activation and cytokine expression in aortas and/or hearts. Aortas and/or hearts isolated from young (3-4 months) and old (23-24 months) WT and Arg-II−/− mice were subjected to (A) immunoblotting analysis of phsopho-p38-Thr180/Tyr182 (p-p38) and total-p38 (p38) in aortas. n=7 mice in each group. (B) qRT-PCR analysis of KC (the murine IL-8 homolog) and IL-6 expression in the heart of young and old mice. n=8 mice in each group. *p<0.05, **p<0.01 vs young wild type (WT) mice; #p<0.05 vs old wild type (WT) mice.