Research Paper Volume 7, Issue 2 pp 110—122

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors


Figure 6. Trajectories of DNA strand break repair. Alkaline DNA unwinding was monitored in cell lysates prepared at the indicated time points subsequent to exposure of the cells to 3.8 Gy (arrows). Values are normalised to the amplitude of the initial IR-induced increase in unwinding. Data represent mean values ± SEM of five independent cell cultures analysed for each individual donor. Numbers on the right margins of the age groups indicate the chronological ages of the donors of the samples.