Research Paper Volume 7, Issue 4 pp 223—232

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity


Figure 2. Deletion of Ppp2cα in the liver improves glucose tolerance (a,b) GTT on male Ppp2cαloxp/loxp: Alb and control mice (n=7-8) on chow diet (a) at 8 weeks of age and on HFD (b) for 8 weeks (16 weeks of age). Bar graphs to the right show the respective area under the curve (AUC) of glucose. (c) Fed and fasting serum glucose levels. (d) Fed and fasting serum insulin levels. (e) ALT activity. Ppp2cαloxp/loxp: Alb and WT: Alb control groups are indicated in the figures. Data are represented as mean ± SEM. Data were analyzed using two-tailed Student's t test (*p < 0.05, **p < 0.01, ***p < 0.001).