Research Paper Volume 7, Issue 4 pp 223—232

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity


Figure 4. Enhanced insulin sensitivity in Ppp2cαloxp/loxp: Alb mice. (a, b) Western blot of insulin signaling involved Akt pathway in the liver (a) and muscle (b). Livers and skeletal muscle of overnight fasted mice on chow were isolated 5mins after 1U/kg insulin treatment. (c) Relative expression of G6P, PEPCK, and PGC1α mRNAs normalized against 36B4 mRNA levels, measured by Q-PCR in livers from fasted overnight mice. Data were analyzed by two-tailed Student's t test (*p < 0.05, ***p < 0.001).