Research Paper Volume 7, Issue 3 pp 205—216

The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells


Figure 7. Schematic diagram of p53/miR-17/Smurf1 cascade. (A, B) p53 regulates the osteogenic differentiation of BMMSCs through inhibiting transcription of miR-17-92 cluster and subsequent modulating Smurf1, a direct target gene of miR-17, aslo acts as a negative regulator for osteogenic differentiation of mesenchymal stem cells.