Research Paper Volume 7, Issue 4 pp 233—240

Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo


Figure 1. Caloric restriction slows cellular growth and improves response to heat shock. (A) B16F10 melanoma cells were maintained in culture with serum from AL- and CR-fed rats over a period of 96 h. The number of cells was counted at 24-h intervals. (B) Percent of cells surviving a 1-h treatment at 45°C when maintained in culture with serum from either AL- or CR-fed rats. Data are represented as the mean ± SEM. *, p< 0.05.