Figure 1. Caloric restriction slows cellular growth and improves response to heat shock. (A) B16F10 melanoma cells were maintained in culture with serum from AL- and CR-fed rats over a period of 96 h. The number of cells was counted at 24-h intervals. (B) Percent of cells surviving a 1-h treatment at 45°C when maintained in culture with serum from either AL- or CR-fed rats. Data are represented as the mean ± SEM. *, p< 0.05.