Figure 2. Caloric restriction decreased melanoma tumor growth in vivo. In AL- and CR-fed mice, mouse tumor xenografts were formed by implanting B16F10 melanoma cells, at the periscapular region (proximal area) and in the lower back over the hip (distal area). Tumor area (mm2) (A) and individual tumor weight (g) (B) were determined after 14 days. Data are represented as the mean ± SEM. n=10/per group. *, p< 0.05, **, p<0.01, *** p<0.001.