Research Paper Volume 7, Issue 4 pp 241—255

Thyroxine modifies the effects of growth hormone in Ames dwarf mice


Figure 9. (A) Signal Transducer and Activator of Transcription (STAT) ‐1, (B) STAT‐5a, (C) STAT‐5b, (D) Adiponectin, and (E) FOXO3 relative gene expression in female Ames dwarf (df/df) mouse white adipose tissue after growth hormone (GH) and thyroxine (T4) treatment. For A‐D, wild‐type (N)n=10;df/dfn =9;df/dfGHn= 9;anddf/dfGH+T4n=8. ForE(FOXO3), Normal(N) n = 10;df/df n=9;df/dfGHn= 9;anddf/df GH+ T4n= 7. Groups that do not share a superscript show differences with statistical significance (p < 0.05). Both GH and GH + T4 treatment decreased PPAR-γ gene expression level in WAT of df/df mice (compared with df/df mice, p <0.05, p< 0.005 respectively). Moreover, animals in the df/df-GH + T4group had lower PPAR-γ expression than the df/df-GH group (p < 0.05) (Figure 8), PGC-1α mRNA levels were significantly increased in the WAT of Ames dwarf mice compared with N controls (p < 0.005).