The cerebellum ages slowly according to the epigenetic clock
Figure 5.Epigenetic age acceleration in two multi-tissue data sets. The first column (a, c) report results for samples from data set 5 . The last column (b, d) reports findings for data set 6 . (a-b) Scatter plots relating the DNAm age of each sample (y-axis) versus the corresponding chronological age (x-axis). Linear regression lines through cerebellar samples and non-cerebellar samples are colored in turquoise and red, respectively. Note that cerebellar samples (turquoise points) tend to lie below non-cerebellar samples. (a) Squares, circles, and triangles correspond to samples from controls, AD, and mixed dementia subjects, respectively. (b) Squares and circles corresponds to controls and schizophrenia subjects, respectively. (c) The barplots depict the mean DNAmAge (y-axis) versus tissue type for all subjects from panel A for whom all 5 tissue types (including whole blood) were available. (d) Analogous plot for all subjects from data set 6 for whom both brain regions were available.