Research Paper Volume 7, Issue 6 pp 383—388

High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to males


Figure 2. High‐glucose diet regulates mobility in a sex‐specific manner. (A) High‐glucose diet (orange bars) decreased male paralysis (increased mobility) and increased hermaphrodite paralysis (decreased mobility) compared to control (black bars) at day 14 of adulthood. (B‐D) Male mobility was analyzed using Multi‐Worm Tracker. (B) Average speed decreases with age on both diets (p < 0.001 by ANOVA), but average speed on high‐ glucose diet was significantly higher than control on day 7 and day 14 (*p < 0.001 by ANOVA). Error bars represent SEM. (C‐D) The distribution of observed speeds was significantly different for males on high‐glucose diet compared to control on day 7 (C) and day 14 (D) (p = 0.02 and 0.004, respectively, by Kolmogorov‐Smirnov Z test).