Figure 8. Age‐dependent changes in gene expression in Bmal1‐/‐ mice. (A) Expression of genes remained stable in young mice (6 weeks old) and didn’t show significant difference between both genotypes. (B) Expression levels of ROS‐induced genes prdx 1 and mt as well as cell cycle inhibitory gene p21Waf1/CIP1 (p21) were significantly higher, while cd1, wee1and bdnf were down‐regulated in hippocampus of adult Bmal1‐/‐ (12 weeks old). Expression level of fgf was not different between both genotypes. Values are shown as mean + SEM. *: P < 0.05, **: P < 0.01.