Editorial Volume 7, Issue 7 pp 459—460

A brave new MYC-amplified world


Figure 1. MYC regulates the expression of noncoding (nc) RNAs. A heatmap of ncRNAs detected in the human B cell line P493–6. P493–6 cells were analyzed by RNAseq in triplicate under conditions of high and low MYC expression. Transcripts are ordered by the change in expression upon MYC upregulation, with those most upregulated at the top and those most downregulated at the bottom. The figure shows that the expression of virtually all ncRNAs is affected by MYC; they are either upregulated or downregulated. There extremely few if any noncoding transcripts that do not respond to MYC.