Research Paper Volume 7, Issue 7 pp 486—499

Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation


Figure 1. Preparation of transgenic mice overexpressing GMF (GMF-TG). (A) This figure shows the construct used to prepare the transgenic mice. The construct was prepared by cloning the coding region of GMF (97–915 bp) in a pCAGGS vector. (B) This figure shows that the gene expression of GMF in the kidney of the GMF-TG mice was significantly higher (about 7-fold) than that of the wild-type (WT) mice. The data is shown as means ± S.E. (WT; n=3, GMF-TG; n=3). *; P < 0.05 vs. WT mice.