Research Paper Volume 7, Issue 7 pp 486—499

Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation


Figure 2. Photograph of WT and GMF-TG mice. (A-B) These photographs show the representative appearance of WT (A) and GMF-TG (B) mice at 80 weeks, respectively. The GMF-TG mice showed alopecia and skin atrophy. These phenotypes were not detected in the aged-matched wild-type mice. (C-D) Indicators of aging phenotypes, such as spinal curvature, were detected in the GMF-TG (D) mice, but not in the WT (C) mice at 110 weeks.