Research Paper Volume 7, Issue 8 pp 535—552

Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms


Figure 6. methuselah-like 3 knockdown fails to extend longevity. (A) Ubiquitous knockdown of mthl3 does not extend lifespan, and in fact reduces longevity of both males and females (log-rank; p <.0001 for each, n ≥ 260). (B) Ubiquitous knockdown of mthl3 improves flight ability of females compared to RU- control (t-test, p = .0001, n ≥ 160), but not males.