Research Paper Volume 7, Issue 8 pp 579—594

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss


Figure 3. Functional categorization of neurological disease and network of canonical pathways objected by IPA using genes differentially expressed in the cochlea of Cmah-null mice. (A) Pie chart analysis of the disease or functions annotation for neurological disease. (B) The network of canonical pathways highlights the relationships between pathways and classifies the functional groups by IPA analysis. Group I and II represent oxidative stress and mitochondrial dysfunction-related signaling (Group I), and Wnt/β-catenin signaling (Group II), respectively.