Editorial Volume 7, Issue 9 pp 609—610

Rac1 GTPase in pancreatic cancer


Figure 1. Effectors of oncogenic K-Ras. K-Ras signals through activation of its downstream effectors: the Ral-GDS, MAPK, PI3K, and Rac1 pathways. Several independent pathways are responsible for Rac1 activation in pancreatic cancer cells, many of which under the control of oncogenic K-Ras (Tiam1, PREX1).