Research Paper Volume 7, Issue 10 pp 793—810

Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients


Figure 3. Effects of age on the values of the biochemical parameters in controls and AD participants. Pearson correlation analysis of age with (A) OCR parameters, (B) ECAR parameters, (C) ROS production, (D) dNTPs, (E) DNA strand breaks, (F) APE1 activity. Units: OCRs (Basal OCR, ATP turnover, Reserve capacity, Maximum capacity, Proton leak), pmol oxygen/min; ECARs (Basal ECAR, Glycolytic reserve), mpH/min; ROS production, fluorescence; dNTPs, pmol/million cells; DNA strand breaks, percent fluorescence; APE1 activity, percent incision.