Research Paper Volume 7, Issue 10 pp 766—775

Telomere length, cardiovascular risk and arteriosclerosis in human kidneys: an observational cohort study


Figure 2. Principal component analysis using the individual histological lesions in kidney biopsies and telomere length in (A) Cohort 1 in (B) Cohort 2. This two‐dimensional scatter represents the histologic lesions according to their score in the loading matrix of a principal components analysis that included the different histological lesions, together with calendar age and telomere length. These analyses illustrated a dichotomy between the histological lesions associated with calendar age and the histological lesions associated with biological age. Calendar age (Age) are glomerulosclerosis (gs), tubular atrophy (ct), interstitial fibrosis (ci) and arteriolar hyalinosis (ah). Arteriosclerosis lesions (cv) clustered with biological age [leucocyte and renal telomere length (TL; log T/S ratio)]. PC1 = Principal Component 1; PC2 = Principal Component 2.