Figure 1. J147 improves locomotor and cognitive function in old SAMP8 mice. Distance travelled (A), average velocity (B), number of jumps (C) and number of vertical events (D) were assessed in young mice and old SAMP8 mice fed with control or J147 diets with the open field test. The elevated plus maze (E) was used to measure anxiety levels. Recognition memory and spatial learning/memory were evaluated by the object recognition (F) and the Barnes maze (G) assays, respectively. One-way ANOVA followed by Tukey-Kramer post-hoc test and two-way repeated measures ANOVA and post hoc Bonferroni corrected t-test (n = 12-16/group). All data are mean ± SD.