Research Paper Volume 7, Issue 11 pp 937—955

A comprehensive multiomics approach toward understanding the relationship between aging and dementia


Figure 2. Dysregulation of neuronal homeostasis and stress responses in the hippocampus of old SAMP8 mice is partially restored by J147. RIPA-soluble fractions from hippocampal tissue were analyzed by Western blotting for relevant markers of neuronal homeostasis and stress and are presented relative to actin or the unphosphorylated molecule: Arc (A), SAP102 (B), eIF2α (C), peIF2α (D), HSP40 (E), HSP60 (F), HSP70 (G), HSP90 (H). One-way ANOVA followed by Tukey-Kramer post-hoc test (n = 6/group). All data are mean ± SD.