Figure 2. Dysregulation of neuronal homeostasis and stress responses in the hippocampus of old SAMP8 mice is partially restored by J147. RIPA-soluble fractions from hippocampal tissue were analyzed by Western blotting for relevant markers of neuronal homeostasis and stress and are presented relative to actin or the unphosphorylated molecule: Arc (A), SAP102 (B), eIF2α (C), peIF2α (D), HSP40 (E), HSP60 (F), HSP70 (G), HSP90 (H). One-way ANOVA followed by Tukey-Kramer post-hoc test (n = 6/group). All data are mean ± SD.