Figure 3. J147 prevents alterations in Aβ and tau homeostasis in the hippocampus of old SAMP8 mice. (A and B) Western blot analysis of APP processing in hippocampal tissue using an antibody against the C-terminus of APP. Full-length APP and the APP cleavage products C99 and C83 were detected. (C) ELISA for Aβ. Western blot analysis of total Tau (D) and pTau Ser396 (E). One-way ANOVA followed by Tukey-Kramer post-hoc test (n = 6/group). All data are mean ± SD.