Research Paper Volume 7, Issue 11 pp 937—955

A comprehensive multiomics approach toward understanding the relationship between aging and dementia


Figure 5. Changes in eicosanoid metabolism of fatty acids in the cortex of young SAMP8, old SAMP8 and old SAMP8 mice fed with J147. Significant changes in the metabolites of arachidonic acid, docosahexaenoic acid, linoleic acid and adrenic acid derived from the actions of COX and cytochrome P450 and non-enzymatic oxidation. One-way ANOVA followed by Tukey-Kramer post-hoc test (n = 5/group). Values are expressed as box-and-whisker plots.