Research Paper Volume 7, Issue 11 pp 1004—1021

Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults


Figure 1. Rate of torque development (RTD) for the knee flexors at baseline and following 10 weeks of placebo (white) or sodium nitrite supplementation (gray – 80 mg/day; black – 160 mg/day). Sodium nitrite supplementation improved knee flexor RTD as shown by time × treatment interaction for three groups (A); * p<0.05). Individual subject data (B) indicated that knee flexor RTD changed little across 10 weeks for the 10 subjects in the placebo group (white circles), but improved for most subjects taking sodium nitrite 80 mg/day (gray circles), and subjects supplemented with 160 mg/day (black circles).