Research Paper Volume 7, Issue 11 pp 1004—1021

Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults


Figure 4. Cognitive function as assessed by time to complete the Trail Making Test-A (A, TMT-A) and -B(B, TMT-B) at baseline and following 10 weeks placebo (white) or sodium nitrite supplementation (gray - 80 mg/day; black - 160 mg/day). Sodium nitrite supplementation tended to improve time to complete TMT-A, an index of processing speed (A; † p<0.1). A significant time × treatment interaction was observed for TMT-B(B; * p<0.05), indicating that sodium nitrite supplementation improved an index of executive function.