Research Paper Volume 7, Issue 11 pp 986—999

Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program


Figure 3. Strongly SASP-inducing kinases display strong associations with the NF-κB signaling pathway. The String database ( used to build networks on the basis of known and predicted protein-protein interactions was interrogated with, as entries, the indicated pro-senescence kinases (orange circles). Enrichment in KEGG pathways was used to identify common signaling pathways for the pro-senescence kinases. Proteins defined as belonging to the NF-κB signaling pathway are highlighted by green circles.