Editorial Volume 7, Issue 11 pp 897—898

Rab1 GTPases as oncogenes


Figure 1. Role of RAB1 in amino acid-Mtorc1 signaling and oncogenic growth. RAB1 mediates amino acid signaling to stimulate mTORC1 activity by recruiting Rheb to mTORC1 on the Golgi membranes, which results in elevated expression of transfer and ribosomal RNA and biosynthetic genes, as well as protein translation. RAB1 overexpression frequently occurs in human cancer, which enhances amino acid-mTORC1 signaling and oncogenic growth.