**Figure 1.** **Epigenetic age of DLPFC samples versus neuropathological measures.** (**A**) Scatter plot relating the DNAm age of each PFC sample (y-axis) versus chronological age at time of death (x-axis). The red line depicts a linear regression line. The y-axis of the remaining panels (**B**-**I**) involves the measure of epigenetic age acceleration which has been adjusted for sex. The scatter plots relate epigenetic age acceleration (y-axis) to (**B**) diffuse plaques, (**D**) neuritic plaques, (**F**) NFTs, and (**H**) amyloid load. The title of each scatter plot reports a robust correlation coefficient (biweight midcorrelation) and a corresponding p-value. (**C,E,G,I**) The x-axis of the bar plots involve a binary grouping variable that results from using the median value for dichotomizing (**C**) diffuse plaques, (**E**) neuritic plaques, (**G**) NFT, and (**I**) beta-amyloid load, respectively. Each bar plot depicts the mean value, one standard error, and reports the p-value results from a non-parametric group comparison test (Kruskal Wallis test). The title of each scatter plot reports a robust correlation coefficient (biweight midcorrelation) and a corresponding p-value.