Research Paper Volume 7, Issue 12 pp 1185—1197

Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality


Figure 4. Changes in the TGFβ downstream signaling proteins in wounds of AT1R−/− and AT2R−/− mice. AT1R−/− mice have lower expression of Smad3 and the common mediator Smad4 in healed skin (day20) as compared to WT. A decrease in the expression of Smad3 was also observed in the AT2R−/− mice. The photomicrographs presented in red fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of Smads in wild-type and mutant mice is shown. Scale bar 200 μm. **p<0.005, ***p<0.0005.