Figure 6. Down regulation of Proliferating Cell Nuclear Antigen in wounds of AT1R−/− and AT2R−/− mice. AT2 R−/− mice have lower expression of total Histone H3 in healed skin (day20) as compared to WT. The photomicrographs presented in green (PCNA) or red (Total Histone H3) fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of PCNA and Histone H3 in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05, **p<0.005 .