Research Paper Volume 7, Issue 12 pp 1185—1197

Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality


Figure 6. Down regulation of Proliferating Cell Nuclear Antigen in wounds of AT1R−/− and AT2R−/− mice. AT2 R−/− mice have lower expression of total Histone H3 in healed skin (day20) as compared to WT. The photomicrographs presented in green (PCNA) or red (Total Histone H3) fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of PCNA and Histone H3 in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05, **p<0.005 .