Research Paper Volume 7, Issue 12 pp 1185—1197

Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality


Figure 7. Down regulation of mitotic histone H3 phosphorylation in wounds of AT1R−/− at several residues, including serine 28 as well as threonine 3 and 11. AT2 R−/− mice have lower expression of Phospho-Histone H3 (Thr3) in healed skin (day20) as compared to WT. The photomicrographs presented in green (Thr3 and S28) or red (Thr11) fluorescent staining with a blue DAPI counter stain for nuclei at 10x magnification. Quantification of mean fluorescence intensity of Phospho-Histone H3 in wild-type and mutant mice is shown. Scale bar 200 μm. *p<0.05, **p<0.005.