**Figure 7.** γH2AX foci, EdU incorporation and SA-βG after cumulative DNA damage. (**A**) Simulated (lines) and measured (symbols) time series of γH2AX foci (mean ± average SEM (3 rep with >50 nuclei each)), respectively. For better visibility of the cumulative damage, the y-axis was pruned at 100 foci. (**B**) Simulated (lines) and measured (symbols) time series of simulated Cdk2 activity (*CycE/Cdk2-a*) and measured EdU incorporation (mean ± SEM (n≥3)), respectively. (**C**) Simulated (open circles) and measured (bars) γH2AX foci 58 days after experiment start (Control) (mean ± average SEM (3 rep with >50 nuclei each)). White dots indicate simulated values from panel A. (**D**) Simulated Cdk2 activity (*CycE/Cdk2-a*) (open circles) and EdU incorporation (bars) (mean ± SEM (n≥3)) 58 days after experiment start (Control), respectively. White dots indicate simulated values from panel B. (**E**) SA-βG activity (mean ± SEM (n≥3)) after 5 Gy IR and 10×2+5 Gy IR 16 days after control (60 days), respectively. (**F**) EdU incorporation after 5 Gy IR and 10×2+5 Gy IR 16 days after control (60 days), respectively (mean ± SEM (n≥3)). **: P<0.05, -: P>0.1, non-paired two-sided t-test.