Research Paper Volume 8, Issue 2 pp 245—259

Figure 3. Har-HK promoter region sequence and activity. (A) Har-HK promoter region nucleotide sequence; nucleotide positions are numbered relative to the predicted transcription start site (+1). The potential consensus sequences for regulatory elements and transcription factor-binding sites are underlined. (B) HK promoter deletion analysis. Diagram of deletion constructs covering various Har-HK promoter regions that were fused to a luciferase reporter gene and then transfected into HzAm1 cells. The pGL3-basic plasmid was used as a negative control, and each point represents the mean ± S.D. of three independent replicates.