Figure 1. The rs11014002 SNP carriers exhibit reduced risk of AD. (A), (B) and (C) Differential analysis of volumes of whole brain, ventricle, hippocampus, entorhinal cortex, and middle temporal cortex and levels of Tau, phosphorylated Tau and Aβ 42 in the cerebrospinal fluid (CSF) of cognitively normal elderly controls (NC), subjects with mild cognitive impairment (MCI) and subjects with Alzheimer's disease (AD) (n = 365, 772 and 301 for NC, MCI and AD subjects, respectively). One-way ANOVA was used for analysis. *P < 0.05, **P < 0.01, ***P < 0.001 versus the NC subjects; ###P < 0.001 versus the MCI subjects. (D) Genotype density among the NC, MCI and AD subjects; chi-square test was used for the analysis. (E) Differential analysis of ages of NC, MCI and AD subjects with the CC genotype and T-carrier genotype (n= 305 and 60 in the NC group; n= 689 and 83 in the MCI group; and n= 267 and 34 in the AD group for CC and T-carrier subjects, respectively). *P < 0.05, versus CC as determined by unpaired two-tailed Student's t-tests.