Research Paper Volume 8, Issue 2 pp 272—290

Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease

Figure 4. miR-603 increases the LRP1 protein levels. (A) Quantitative RT-PCR analysis of mRNA (right) and immunoblot analysis of protein (left) levels of LRP1 following the overexpression of miR-603 in HEK293 cells. (B) Quantitative RT-PCR analysis of mRNA (right) and immunoblot analysis of protein (left) levels of LRP1 following the inhibition of endogenous miR-603 in HEK293 cells. (C, D) Immunoblot analysis of protein levels of LRP1 following the overexpression of miR-603 (C) and the inhibition of endogenous miR-603 (D) in HeLa cells. *P < 0.05, **P < 0.01, ***P < 0.001 versus NC as determined by paired two-tailed Student's t-tests for quantitative RT-PCR analysis and by unpaired two-tailed Student's t-tests for immunoblot analysis.