Research Paper Volume 8, Issue 2 pp 272—290

Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease

Figure 5. Profiles of differentially expressed genes (DEGs) targeted by miR-603 as determined by Gene Ontology (GO) and pathway analysis. (A) The fifteen most significantly downregulated biological processes and the fifteen most significantly downregulated pathways in HEK293 cells are shown. Fisher's exact test and χ2 test were used to classify the GO category and to select the significant pathway, and the threshold of significance was identified by P <0.05 and FDR < 0.05. (B) Quantitative RT-PCR analysis of RND1 mRNA levels following the overexpression of miR-603 and the inhibition of miR-603 in HEK293 cells and HeLa cells. *P < 0.05, **P < 0.01, ***P < 0.001 versus NC as determined by a paired two-tailed Student's t-tests for quantitative RT-PCR analysis.