Figure 8. Working model. The rs11014002 SNP in pre-miR-603 increases the expression of miR-603, which may account for a reduced AD risk. miR-603, which targets LRPAP1 and increases the LRP1 protein levels, may promote Aβ clearance in the brain. miR-603 can prevent cells from undergoing apoptosis possibly by downregulating E2F1. In the hippocampi of patients with AD, miR-603 loses its regulatory role and manifests a compensatory increase.