Research Paper Volume 8, Issue 2 pp 216—230

Placental membrane aging and HMGB1 signaling associated with human parturition

Figure 3. Canonical pathways identified by IPA analysis. (A) TNIL vs TL. IPA analysis of differentially regulated SASP genes demonstrate pathways affected by these genes. Various forms of inflammation are impacted by these genes; a notable one is HMGB1 signaling that was reported to be a product of senescent placental membrane cells. (B) Control vs CSE: IPA analysis of differentially regulated SASP genes demonstrate pathways affected by these genes. Various forms of inflammation are impacted by these genes. One of the notable top 5 functions is HMGB1 signaling which was reported to be a product of senescent placental membrane cells. This pathway was seen in TNIL vs TL membranes (Figure1G).