Research Paper Volume 8, Issue 2 pp 216—230

Placental membrane aging and HMGB1 signaling associated with human parturition

Figure 4. HMGB1 in placental membranes. (A) HMGB1 concentration in the cytoplasmic fraction of placental membranes from TL was marginally higher (P = .07) than from TNIL. (B) COX-2 expression was increased in myocytes (n=6) after HMGB1 treatment compared to controls. (C) Connexin-43 expression was not different after HMGB1 treatment in myocytes compared to control. (D-F) Inflammatory cytokine genes IL-6 (D) and TNFα (E) were increased, whereas no change was seen in IL-8 expression (F).