**Figure 6.** **Ratios of metabolites demonstrating significant differences between Gulo^{−/−} mice treated with different concentrations of ascorbate.**

**(A)** Graph showing the Met-SO/Met ratio in the different groups of mice. Tukey post ANOVA test **P*-value < 0.05. **(B)** Graph showing the Tyr/Phe ratio in the different groups of mice. Tukey post ANOVA test **P*-value < 0.05. **(C)** Graph showing the Arg/Lys ratio in the different groups of mice. Tukey post ANOVA test **P*-value < 0.05. **(D)** Graph showing the Arg/Orn ratio in the different groups of mice. Tukey post ANOVA test **P*-value < 0.05. **(E)** Graph showing the C0/C4:1 ratio in the different groups of mice. Tukey post ANOVA test ***P*-value < 0.01. **(F)** Graph showing the C0/C16-OH ratio in the different groups of mice. Tukey post ANOVA test *P*-values are shown (**P* < 0.05 and ***P* < 0.01). **(G)** Graph showing the ratio of saturated/unsaturated phosphatidylcholine species from the Figure *P*-value < 0.05. **(H)** Graph showing the PC aa C36:0/PC aa C36:2 ratio in the different groups of mice. Tukey post ANOVA test ***P*-value < 0.01.