Research Paper Volume 8, Issue 2 pp 366—381
Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase
Figure 6. CDK inhibitor accelerates senescence in HGPS fibroblasts. (A) Population doublings calculated after serial passage of the cells starting at population doubling 9 and treated with vehicle or 60 nM flavopiridol for the indicated amount of days. (B) Immunoblots in cells as in (A) for the indicated proteins.