Research Paper Volume 8, Issue 2 pp 382—393

Telomere shortening leads to earlier age of onset in ALS mice


Figure 2. Cell type specific telomere length in hippocampal tissue of ALS- patients and non-neurological control-individuals. Telomere fluorescence intensity (TFI) of astroglia, microglia and neurons was measured using a combined protocol for qFISH and immunhistochemistry. Subsequently TFI was converted into Telomere length (TL) using a linear equitation resulting from qFISH and linear regression analysis of five selected cell lines with defined and stable telomere length. Values represent the mean ± SEM. P-values are sex- and age- adjusted based on an appropriate multiple linear regression model.