Research Paper Volume 8, Issue 3 pp 484—505

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4


Figure 10. The miR-15b - SIRT4 axis regulates the expression of nuclear encoded mitochondrial genes. Inhibitors against miR-15b were transfected in primary human dermal fibroblasts in the absence or presence of siRNA duplexes against SIRT4. Transcript levels of CytC (A), TFAM (B), and NRF1 (C) were determined by qRT-PCR. Shown are mean ± s.d. values from nine to thirteen experiments. To evaluate statistical significance, ANOVA on ranks Dunn´s tests were performed (*p<0.05).