Research Paper Volume 8, Issue 4 pp 664—684

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice


Figure 8. Global 5-methylated cytosine (A) and 5-hydroxymethylated cytosine levels (B) in female mice aged 2 and 8 months (Wt and 5XFAD). Gene expression for Dnmt1 (C), Dnmt3a (D), Dnmt3b (E), Tet1 (F), and Tet 2 (G). Gene expression levels were determined by real-time PCR. Mean ± Standard Error of the Mean (SEM) from five independent experiments performed in triplicate are represented. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.