Editorial Volume 8, Issue 2 pp 210—211

Copper that cancer with lysosomal love!


Figure 1. The ability of Dp44mT to overcome drug resistance is mediated by its ability to be transported into the lysosome by the drug transporter, P-glycoprotein (Pgp). Subsequently, within the lysosome, Dp44mT binds Cu and then redox cycles to generate cytotoxic reactive oxygen species (ROS) that subsequently results in lysosomal membrane rupture. The rupture of the lysosome leads to the release of enzymes such as cathepsins that trigger apoptosis and cell death [6, 7]. Hence, resistant cells with high Pgp expression then become sensitive to Dp44mT, leading to increased cell death, and thus, overcoming the multi-drug resistance (MDR) phenotype.