Research Paper Volume 8, Issue 3 pp 521—533

Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid


Figure 4. PLSDA analysis of all 45101 probes of three differently treated groups. (A). A heat map of all 568 differentially expressed genes between BS-I treated and vehicle-treated groups APP/PS1 mouse brains (B). The mRNA expression patterns of 10 selected genes in the brain of BS-I-treated and vehicle treated APP/PS1 mice compared with wild-type mice assessed by real-time PCR agreed with the cDNA microarray results (C). The data are presented as the standard error of the mean (SEM); * p < 0.05, ** p < 0.01, *** p < 0.001.